Apoptosis (programmed cell death) is an evolutionarily conserved cellular process, important for development and homeostasis(1). Most apoptotic cells share a common set of morphological and physiological characteristics that distinguish them from necrotic deaths(2). While genetic studies have indicated that these characteristic changes result from the activation of an endogenous ‘suicide program’(3), little is known about the nature of this program and the molecular events underlying these changes. Two recent papers(4,5) describing cell‐free extracts that reproduce several of the characteristic changes observed (...) in apoptotic cells promise to make these phenomena accessible to biochemical analysis. (shrink)

The introduction of Western healthcare, via colonialism, into Africa facilitated a confrontation of indigenous and exogenous “medical” knowledge as well as the attendant praxis. Although colonialism has been expunged from the shores of Africa, the epistemic and ideological frictions it introduced into the sphere of healthcare linger and raise different dilemmas. Against this background, this paper explores pragmatic and ethical approaches that may help engage these tensions in the context of drug development based on validated traditional phytomedicines.

Many scholars and activists seek to eliminate “race”—the word and the concept—from our vocabulary. Their claim is clear: because science has shown that racial essentialism is false and because the idea of race has proved virulent, we should do away with the concept entirely. Michael O. Hardimon criticizes this line of thinking, arguing that we must recognize the real ways in which race exists in order to revise our understanding of its significance. Rethinking Race provides a novel answer to (...) the question “What is race?” Pernicious, traditional racialism maintains that people can be judged and ranked according to innate racial features. Hardimon points out that those who would eliminate race make the mistake of associating the word only with this view. He agrees that this concept should be jettisoned, but draws a distinction with three alternative ideas: first, a stripped-down version of the ordinary concept of race that recognizes minimal physical differences between races but does not consider them significant; second, a scientific understanding of populations with shared lines of descent; and third, an acknowledgment of “socialrace” as a separate construction. Hardimon provides a language for understanding the ways in which races do and do not exist. His account is realistic in recognizing the physical features of races, as well as the existence of races in our social world. But it is deflationary in rejecting the concept of hierarchical or defining racial characteristics. Ultimately, Rethinking Race offers a philosophical basis for repudiating racism without blinding ourselves to reality. (shrink)

Volume 19, Issue 7, July 2019, Page 53-55.

Funding broadly connotes the notion of an institution and/or institutions making money and other resources available to individual researchers and organizations to accomplish specific projects. Whi...

One of the central characteristics of public health disasters is the rapid overlapping of different needs and priorities that require making critical choices that inevitably elicit conflicti...

This book provides an authoritative account of Hegel's social philosophy at a level that presupposes no specialised knowledge of the subject. Hegel's social theory is designed to reconcile the individual with the modern social world. Michael Hardimon explores the concept of reconciliation in detail and discusses Hegel's views on the relationship between individuality and social membership, and on the family, civil society, and the state. The book is an important addition to the string of major studies of Hegel published (...) by Cambridge. It will interest a broad swathe of readers in philosophy, (both students and specialists), and could be used in courses on political and social theory. -/- "Michael Hardimon's carefully and clearly argued, deeply nuanced book represents an important contribution to the ongoing Hegel renaissance. A short review can never do justice to such a richly argued work so replete with detail and example. Hegel scholars will learn much from it, and those innocent of Hegelian language will find it a good place to begin." Terry Pinkard, Ethics -/- "Micahel Hardimon's new book is a valuable study of Hegel's social and political philosophy....Hardimon deliberately resists using Hegel's technical terminology and engaging in detailed scholarly disputes in a successful effort to avoid obscurity and distraction. The result is a book that should be prized by anyone seeking an accessible presentation of Hegel's social philosophy, particularly as a vehicle for teaching Hegel's political thought without having to devote an entire course to the task." The Philosophical Review. (shrink)

Volume 24, Issue 10, October 2024, Page 103-106.

The ordinary concept of race is important and poorly understood. The present article seeks to address this problem by providing a general answer to the question: What is the concept of race?

This essay presents four ways of thinking about race. They consist of four related but distinct race concepts: the racialist concept of race, which is the traditional, pernicious, essentialist, and hierarchical concept of race; the concept of socialrace, which is the antiracist concept of race as a social construction; the minimalist concept of race, which is the deflationary concept of biological race that represents race as a matter of color, shape and geographical ancestry; and the populationist concept of race, the (...) race concept that represents races as populations, deriving from geographically separated and reproductive isolated founding populations. Taken together, the four concepts can help us better navigate our way through the murky conceptual domain of “race.”. (shrink)

Why do otherwise well-intentioned managers make decisions that have negative social or environmental consequences? To answer this question, the authors combine the literature on construal level theory with the compromise effect to explore the circumstances that lead to seemingly unethical decision-making. The results of two studies suggest that the degree to which managers make high-risk tradeoffs is highly influenced by how they mentally represent the decision context. The authors find that managers are more likely to make seemingly unethical tradeoffs when (...) psychological distance is high (rather than low) and when they are forced to choose between competing alternatives. However, when given the option not to choose, managers better reflect on the consequences of each alternative, and thus become more likely to choose options with less risk of negative consequences. The results suggest that simply offering managers the option not to choose may reduce psychological distance and help organizations avoid seemingly unethical decision-making. (shrink)

An incoherent visualization is when aspects of different senses of a word are present in the same visualization. We describe and implement a new model of creating contextual coherence in the visual imagination called Coherencer, based on the SOILIE model of imagination. We show that Coherencer is able to generate scene descriptions that are more coherent than SOILIE's original approach as well as a parallel connectionist algorithm that is considered competitive in the literature on general coherence. We also show that (...) co-occurrence probabilities are a better association representation than holographic vectors and that better models of coherence improve the resulting output independent of the association type that is used. Theoretically, we show that Coherencer is consistent with other models of cognitive generation. In particular, Coherencer is a similar, but more cognitively plausible model than the C3 model of concept combination created by Costello and Keane. We show that Coherencer is also consistent with both the modal schematic indices of perceptual symbol systems theory and the amodal contextual constraints of Thagard's theory of coherence. Finally, we describe how Coherencer is consistent with contemporary research on the hippocampus, and we show evidence that the process of making a visualization coherent is serial. (shrink)

This article explores the role of nature in two strands of contemporary materialist philosophy: new materialism, and transcendental materialism. Through an analysis of these strands of materialism via the work of Jane Bennett, William E. Connolly, Catherine Malabou, and Adrian Johnston, the article attempts to delineate these perspectives into the opposed camps of monist and dialectical materialisms. The implications of these differing materialist ontologies are then discussed in terms of the theorization of nature as either a vital material force or (...) as a weakness characterizing matter itself. After outlining the importance of nature for these two opposed theories, the lack of serious engagement with the work of F.W.J. Schelling by either group is discussed as a potential middle ground between the Spinozism of the new materialism and the Hegelianism of transcendental materialism, due to its large-scale political analysis, less pessimistic perspective towards the possibility of a contemporary humanism, and embrace of recent advances in the empirical sciences. (shrink)

Joshua Glasgow has written a wonderful book on race (Glasgow 2009). Thoughtful, clear, and provocative, it advances the discussion in significant ways. Space is limited so I hope I can be excused for restricting my comments to Glasgow’s assessment of my 2003 Journal of Philosophy analysis of the ordinary concept of race. The last thing I would want to suggest is that this exhausts the interest of his book; for that is certainly not the case. My remarks can be regarded (...) as testimony to just how stimulating his fine account is. (shrink)

This paper explores possible connections between gender and the willingness to engage in unethical business behavior. Two approaches to gender and ethics are presented: the structural approach and the socialization approach. Data from a sample of 213 business school students reveal that men are more than two times as likely as women to engage in actions regarded as unethical but it is also important to note that relatively few would engage in any of these actions with the exception of buying (...) stock with inside information. Fifty percent of the males were willing to buy stock with insider information. Overall, the results support the gender socialization approach. (shrink)

Do pharmaceutical companies have a moral obligation to expand access to investigational drugs to patients outside the clinical trial? One reason for thinking they do not is that expanded access programs might negatively affect the clinical trial process. This potential impact creates dilemmas for practitioners who nevertheless acknowledge some moral reason for expanding access. Bioethicists have explained these reasons in terms of beneficence, compassion, or a principle of rescue, but their arguments have been limited to questions of moral permissibility, leaving (...) for future research the question of whether expanded access is morally obligatory. We take up this further question and argue that pharmaceutical companies have a moral obligation to expand access. Our defense is not based on beneficence, compassion, or rescue, but instead on a reciprocal moral expectation resulting from existing social commitments that help ensure a robust pharmaceutical practice within the broader healthcare system. Our aim is to give this obligation, along with several others, a coherent and plausible structure within the wider clinical trial process so that one might better explain the sources of the dilemmas and their possible resolutions. (shrink)

Explication of the concept of socialrace: the concept variously refers to (1) a social group that is taken to be a racialist race, (2) the social position occupied by a particular social group that is a socialrace and (3) the system of social positions that are socialraces. Socialrace is distinguished from other more familiar forms of social construction. The sense in which socialrace counts as a race concept is explained. The advantages of the term ‘socialrace’ are discussed. The desiderata for (...) a conception of socialrace are articulated. The concept socialrace is contrasted with other similar concepts. (shrink)

This article challenges the orthodox view that there is and can be no scientifically valid concept of race applicable to human beings by presenting a candidate scientific concept of biological race. The populationist concept of race specifies that a “race” is a subdivision of Homo sapiens—a group of populations that exhibits a distinctive pattern of genetically transmitted phenotypic characters and that belongs to an endogamous biological lineage initiated by a geographically separated and reproductively isolated founding population. The viability of the (...) PRC is shown by demonstrating its capacity to withstand a wide range of objections. A common theme is that the objections turn on misconceptions of the idea of a scientific concept of race. The final section argues that the PRC will not foster racism. (shrink)

In British Columbia, brown bears , black bears , and cougars must relate to growing human populations. This study examines age- and gender-related attitudes to these animals in the urbanizing, agriculturally significant, intermontane city of Kamloops. Most respondents, especially women, feared cougars and bears, saw bears as more troublesome than cougars, and were concerned for child and adult safety. More middle-aged and older participants perceived brown bears as dangerous to companion animals, and black bears as troublesome, than did younger participants, (...) and more middle-aged participants perceived brown bears as troublesome than did younger and older participants. Opinions favored trapping and removal of animals rather than shooting or toleration, but more younger participants opted for shooting, whereas more middle-aged and older participants opted for toleration and removal. Majorities agreed that the animals serve useful functions, women more than men for cougars, middle-aged more than old or young for bears, but saw only cougars as increasing their quality of life. These findings contribute to knowledge about human-wildlife relations, an important first step toward more efficient local and more general conservation policy. (shrink)

Kierkegaards deiktische Theologie wird in einer Reihe von Textinterpretationen entwickelt, die seine oft übersehenen erbaulichen Reden in einem neuen Licht präsentieren. Das Buch setzt sich mit dem traditionellen Bild der Religiosität bei Kierkegaard auseinander, wie sie in den Begriffen der Religiosität A und B zum Ausdruck kommt, und bringt neue Argumente im Sinne einer deiktischen Theologie. Sie wird in einer doppelten Perspektive entfaltet: Der Mensch richtet seinen Blick auf Gott - und Gott begegnet ihm, indem er den Menschen auf seinen (...) Nächsten hinweist. Deiktische Theologie ist weder eine Schöpfungstheologie (Religiosität A) noch eine Offenbarungstheologie (Religiosität B), sondern sie erfasst die Spannung zwischen Schöpfung und Offenbarung, die u.a. im trinitarischen Gottesbegriff begründet wird. Die Entwicklung der deiktischen Theologie Kierkegaards geschieht in der Interpretation zentraler Texte aus den erbaulichen Reden, der Einübung im Christentum sowie der Unwissenschaftlichen Nachschrift. Wichtige Themen sind darüber hinaus: die Zeitlichkeit, das Verhältnis zwischen dem Humanen und dem Christlichen, die Reue, die Sünde, das Abendmahl, das Leiden, die Nachfolge Christi, Himmelfahrt und Auferstehung. (shrink)

In the last few decades, several philosophers have written on the topic of moral revolutions, distinguishing them from other kinds of society-level moral change. This article surveys recent accounts of moral revolutions in moral philosophy. Different authors use quite different criteria to pick out moral revolutions. Features treated as relevant include radicality, depth or fundamentality, pervasiveness, novelty and particular causes. We also characterize the factors that have been proposed to cause moral revolutions, including anomalies in existing moral codes, changing honour (...) codes, art, economic conditions and individuals or groups. Finally, we discuss what accounts of moral revolutions have in common, how they differ and how moral revolutions are distinguished from other kinds of moral change, such as drift and reform. (shrink)

This book offers an examination of the political and ontological significance of the authorship of Søren Kierkegaard in relation to German Idealism and contemporary European philosophy.

A shift in popular discourse over the last few years makes it makes it tempting to think that the answer to the question whether racism is essentially systemic is yes. My argument, however, is that there are forms of racism—things that are properly counted as instances of racism—that are distinct from and independent of systemic racism. These include ideational racism, ideological racism, racism as antipathy, and racism as prejudice and bigotry. Systemic racism does exist and is not reducible to these (...) other forms of racism. It is arguably the form of racism that should be of most concern to us, but it is not the only form that racism takes. (shrink)

Pragmatic clinical trials (PCTs) seek to show the effectiveness of treatments in routine, clinical practice (MacPherson 2004). However, a number of ethical challenges come to the fore when collater...

Adrian Johnston is well known for his work at the intersection of Lacanian psychoanalysis, German idealism, contemporary French philosophy and most recently cognitive neuroscience. In the context of the current issue, Johnston represents the most complete development of a contemporary theory of Transcendental Materialism. In the following interview we explore both the implications of Johnston’s previous work, as well as the directions his most recent projects are taking.

The power of the scientific enterprise presents multiple avenues for harnessing and increasingly controlling biological phenomena and instituting interventions in different areas of biomedicine (Af...

Explication of the concept of socialrace: the concept variously refers to (1) a social group that is taken to be a racialist race, (2) the social position occupied by a particular social group that is a socialrace and (3) the system of social positions that are socialraces. Socialrace is distinguished from other more familiar forms of social construction. The sense in which socialrace counts as a race concept is explained. The advantages of the term ‘socialrace’ are discussed. The desiderata for (...) a conception of socialrace are articulated. The concept socialrace is contrasted with other similar concepts. (shrink)